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pentobarbital will increase the stage or effect of ivosidenib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of ivosidenib with sturdy CYP3A4 inducers lowered ivosidenib plasma concentrations.pentobarbital will lower the extent or effect of theophylline by influencing hepatic/intestinal enz